Changes In Hypothalamic Leptin Sensitivity After Acute And Repeated Neurogenic Stress.
نویسندگان
چکیده
منابع مشابه
Environment, Leptin Sensitivity, and Hypothalamic Plasticity
Regulation of feeding behavior has been a crucial step in the interplay between leptin and the arcuate nucleus of the hypothalamus (ARC). On one hand, the basic mechanisms regulating central and peripheral action of leptin are becoming increasingly clear. On the other hand, knowledge on how brain sensitivity to leptin can be modulated is only beginning to accumulate. This point is of paramount ...
متن کاملHypothalamic PKA regulates leptin sensitivity and adiposity
Mice lacking the RIIβ regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) display reduced adiposity and resistance to diet-induced obesity. Here we show that RIIβ knockout (KO) mice have enhanced sensitivity to leptin's effects on both feeding and energy metabolism. After administration of a low dose of leptin, the duration of hypothalamic JAK/STAT3 signalling is increased, result...
متن کاملChanges in hypothalamic-pituitary-adrenal stress responsiveness before and after puberty in rats.
This article is part of a Special Issue "Puberty and Adolescence". Many endocrine changes are associated with pubertal and adolescent development. One such change is the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to physical and/or psychological stressors. Recent human and non-human animal studies have shown that hormonal stress reactivity increases significantly throughout...
متن کاملLeptin in functional hypothalamic amenorrhoea.
BACKGROUND Leptin, body weight, body mass index (BMI) and other hormones in women with functional hypothalamic amenorrhoea (FHA) were investigated and the hypothesis proposed that energy imbalance is the predominant mechanism for leptin reduction in patients with FHA. METHODS Eighty-eight women with FHA and 65 age- and weight-matched controls were divided into homogeneous groups on the basis ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.lb42-c